All You Need to Know About Stem Cell Therapy Biology Diagrams Human embryonic and pluripotent stem cells are known to have minimal regulatory control across phases of the cell cycle and be refractory toward growth inhibitory signals. As a result, oscillation of gene expression across phases of the cell cycle is modest in hPSCs 25 - 27 . (a) Stem cells exposed to cell fate specification cues differentiate as an asynchronous wave.(b) The asynchronous differentiation program can be accounted for by the activation of developmental genes in G1-phase of the cell cycle. Cells in G1 respond rapidly to differentiation cues whereas cells in S-, G2-and M-phase experience a delay, indicated by the kinetics of transcriptional activation. Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our curre โฆ
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of โฆ Pluripotency is also linked with cell-cycle regulation because studies in mouse ESCs (mESCs) have shown that their pluripotent status is associated with a specific cell-cycle profile characterized by a shortened G1 phase and the lack of G1 checkpoint regulation (Coronado et al., 2013; Savatier et al., 1996).In conventional cells, cyclin D1-3 are expressed in G1 phase and control the activity
Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells ... Biology Diagrams
The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135-47 (2013). Article CAS Google Scholar Singh, A. M. et al. Cell-Cycle Control of Developmentally Regulated
Stem cell self-renewal is intrinsically associated with cell cycle control. However, the precise mechanisms coordinating cell fate choices and cell cycle remain to be fully uncovered. Now in Cell, Gonzales et al. (2015) and colleagues demonstrate that factors controlling the G2/M phase are necessary to block pluripotency upon induction of differentiation. The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar
